Development of new regenerative approaches for heart failure in children

This project has two main aims:

1. To determine whether the human heart possesses regenerative capacity at early stages of development using non-diseased transplant donor and CHD heart samples, and
2. To develop pre-clinical regenerative therapeutics (small molecules, gene therapies).

We recently performed Single Cell RNA sequencing analysis on non-diseased transplant donor and CHD heart samples. In terms of pre-clinical regenerative therapeutics, CardioRegen investigators Porrello and Elliott recently published a small molecule screen in Cell Stem Cell using human pluripotent stem cell (PSC) derived cardiac organoids.